Unleashing the Therapeutic Potential of RNA, One Structure at a Time
From secondary structure, to 3D structure,
to enabling structure-based SAR.
about a-form solutions
A-Form Solutions is your trusted partner in RNA structural biology.
At A-Form Solutions, we harness the power of cryo-electron microscopy (cryo-EM) to unlock the potential of RNA as a therapeutic target. Our proprietary and transformative scaffolding platform has redefined the industry standard enabling efficient, consistent, atomic-resolution determination of RNA and RNA-ligand (and drug) structures.
services
What We Do
Our cryo-EM platform yields RNA structures of unprecedented resolution. Simply provide us with a secondary structure of your RNA. Our approach routinely yields 3D reconstructions of 3.5 Å or better.
Services can be customized to fit your needs. Contact us and we will find an option that is right for you.
how it works
See It In Action
The reconstruction is at nucleotide resolution in the core, allowing for clear characterization of RNA-ligand interactions. The client provides a secondary structure model, we execute the rest.
Phase 1
- Construct design
- Gene synthesis
Phase 2
- In vitro transcription and RNA purification
- Biochemical assessment of RNA quality
Phase 3
- Grid prep optimization
- Initial data collection and processing
Phase 4
- Large scale data collection and data processing
- Data transfer
Phase 3
- Grid prep optimization
- Initial data collection and processing
Phase 4
- Large scale data collection and data processing
- Data transfer
Partner with Us
Partner with A-Form Solutions for Unparalleled Results
Structures were determined at A-Form Solutions
~400 nt 2.4 Å
~80 nt 3.0 Å
~80 nt 3.0 Å
~80 nt 2.6 Å
RNP 3.0 Å
about
Our A-Team
Daniel Haack, Ph.D.
Co-Founder/CEO
Dan Haack is a leading expert in the field of RNA structural biology. He has solved over 50 RNA structures using cryo-EM and is the co-inventor of the patented high-resolution scaffolding method used at A-Form Solutions.
Navtej Toor, Ph.D.
Co-Founder
Navtej Toor is a Professor of Chemistry and Biochemistry at UC San Diego. His lab studies the structural biology of RNA and RNA protein complexes. He has 25+ years of experience studying RNA structure and function.
Kevin Weeks, Ph.D.
Co-Founder
contact
Interested in learning more about our services?
To learn more about working with A-Form Solutions as your structural biology partner or to set up a confidential consultation, please contact us at: inquiries@aformsolns.com